MabSelect™ PrismA is a protein A resin of which both the ligand and the base matrix have been optimized. The resin exhibits improved capacity over its predecessor MabSelect SuRe™ products, while maintaining purification performance. This application note demonstrates the binding capacity and purification performance of MabSelect PrismA in comparison with its predecessor products for both polyclonal and monoclonal antibodies. An independent end-user evaluation of the performance is also shown.