Downstream - Bioprocess Development Forum

Articles BioPharma Downstream Upstream

January 31, 2019

Modeling the Degradation of mAb Therapeutics

Ensuring the stability of biotherapeutic products, which has an impact on their safety and...

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Articles BioPharma Downstream

January 17, 2019

A Look at the Affinity Chromatography Landscape

Affinity chromatography offers the high selectivity required for biopharmaceutical manufacturing and analysis. Specific binding...

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Articles BioPharma Downstream Regulatory

December 20, 2018

Achieving Process Balance with Perfusion Bioreactors

Perfusion cell-culture processes have been used for more than two decades for the production of...

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Articles BioPharma Downstream Regulatory

September 27, 2018

Ensuring Viral Safety of Viral Vaccines and Vectors

Vaccines, including viral vaccines, are a crucial invention in human history and continue to...

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Articles Downstream

July 2, 2018

Developing an Efficient Adenovirus Downstream Purification Process

Adenovirus is one of the most frequently used viral vectors in the development of therapeutic...

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Articles BioPharma Downstream Upstream

July 2, 2018

Challenges in Cell Harvesting Prompt Enhancements

Cell harvesting is a crucial step that can have significant impact on product quality and…

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Articles BioPharma Downstream Regulatory

June 7, 2018

Putting Viral Clearance Capabilities to the Test

Drug products based on live cells have an inherent risk for viral contamination that could…

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Articles Downstream

March 1, 2018

Impurity Testing of Biologic Drug Products

Experts share insights on the various methods used for purity and impurity analysis of therapeutic...

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Articles BioPharma Downstream Regulatory

February 15, 2018

Preclinical Evaluation of Product Related Impurities and Variants

The approaches for sample preparation of preclinical evaluation of safety and efficacy are...

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Articles Downstream

November 2, 2017

Development of Purification for Challenging Fc-Fusion Proteins

Recent advances in mammalian cell culture processes have significantly increased product titers, but...

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