Downstream - Bioprocess Development Forum

Articles Downstream Regulatory Upstream

March 16, 2016

Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge

The necessity to detach cells from a culture substrate during cell harvesting remains one of…

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Articles BioPharma Downstream Upstream

January 21, 2016

Going Small to Achieve Success on the Commercial Scale

Biopharmaceutical manufacturing involves a series of complex unit operations linked together to...

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Articles BioPharma Downstream Regulatory Upstream

November 19, 2015

Selecting the Right Viral Clearance Technology

The introduction of adventitious viral agents is a recognized, inherent risk of biologic drug...

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Articles BioPharma Downstream Regulatory Upstream

September 10, 2015

Best Practices in Qualification of Single-Use Systems

Single-use technology has been around for approximately two decades if disposable capsule filters...

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Articles Downstream

August 13, 2015

Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification

An important area of focus for the biopharma industry is the elucidation and development of...

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Articles Downstream Regulatory Upstream

June 4, 2015

Host-Cell Protein Measurement and Control

Host-cell proteins (HCPs) constitute a major part of process-related impurities during biologics...

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Articles BioPharma Downstream Regulatory

May 1, 2015

Modular Manufacturing Platforms for Biologics

It should come as no surprise that the good design principles governing pharmaceutical manufacturing…

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Articles Downstream

April 8, 2015

Re-use of Protein A Resin: Fouling and Economics

In the past two decades, Protein A affinity chromatography has remained the de facto capture…

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Articles BioPharma Downstream Regulatory Upstream

April 8, 2015

Continuous Manufacturing: A Changing Processing Paradigm

Although continuous manufacturing is well established for bulk chemicals, complex automation and...

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Articles BioPharma Downstream Regulatory Upstream

April 6, 2015

Use of Multivariate Data Analysis in Bioprocessing

The ever increasing demand of biotherapeutics, together with the pressure to contain healthcare...

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