Upstream - Bioprocess Development Forum

Articles Upstream

January 12, 2023

rAAV Production Using HEK293 Cell Line and Transfection Medium

Improving the performance of a scalable AAV process in Xcellerex™ XDR-10 and XDR-200 bioreactor...

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Articles BioPharma Downstream Upstream

January 13, 2022

Enhancing Resins Addresses Purification Concerns

There is ongoing enhancement of downstream chromatography resins as biomanufacturers...

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Articles Upstream

November 18, 2021

Scaling Up an E. coli Upstream Process for Plasmid DNA Production — from 2.5 to 160 L scale Fermenters

This article summarizes the results of Escherichia coli growth performance for plasmid...

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Articles Upstream

November 18, 2021

Maximum Output Starts with Optimized Upstream Processing

Significant growth in the development and manufacturing of biologics—from traditional recombinant...

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Articles BioPharma Downstream Upstream

November 4, 2021

Large-Scale Single-Use Bioreactors Prove Mettle Amid Growing Demand

The 2000-L-scale SUB has been the mainstay of large-scale SUBs since its introduction. Yasser...

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Articles Upstream

October 21, 2021

Cell Culture Media Selection Guide for Your Lab Wall

Doing cell culture and upstream process development on antibodies, vaccines, or viruses?

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Articles Downstream Upstream

September 9, 2021

Antibody Production Workflow

Antibody-based therapies have evolved beyond monoclonal antibodies (mAbs) to include bispecific...

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Articles BioPharma Downstream Regulatory Upstream

August 30, 2021

Cell-free Expression Systems Pose Cell Culture Alternative

Among the challenges in upstream bioprocessing is the cellular waste generated as a by-product...

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Articles BioPharma Downstream Upstream

August 30, 2021

Single-Use Technologies Prove Effective for Viral Vector Process Development

Upstream viral-vector processes can have significant impacts on downstream purification requirements. The presence...

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Articles Downstream Regulatory Upstream

July 15, 2021

Assessing Manufacturing Process Robustness

The pharmaceutical regulatory landscape and pharmaceutical development have been reshaped by...

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