Upstream - Bioprocess Development Forum

Articles BioPharma Upstream

September 12, 2019

Cell-Culture Advances Test Bioreactor Performance Models

Modeling and simulation are recognized to provide assistance in predicting bioreactor...

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Articles Downstream Upstream

August 15, 2019

Monitoring and Control of Inline Dilution Processes

Buffer management has received less attention in process intensification despite the high costs and...

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Articles Downstream Regulatory Upstream

July 18, 2019

Design Considerations for a Commercial Cell and Gene Therapy Facility

The commercialization of cell and gene therapies has become a reality, prompting deeper...

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Articles BioPharma Downstream Regulatory Upstream

July 2, 2019

Addressing the Complex Nature of Downstream Processing with QbD

Regulators have been encouraging bio/pharmaceutical companies to incorporate the concept of...

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Articles BioPharma Downstream Regulatory Upstream

June 20, 2019

Moving PAT from Concept to Reality

Process analytical technology (PAT) is applied in the biopharmaceutical industry for analysis of raw...

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Articles BioPharma Downstream Upstream

May 9, 2019

Single-Use for Downstream Chromatography: Benefit or Hindrance?

Biopharmaceutical manufacturers have embraced the use of single-use technology upstream, but are...

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Articles Upstream

May 9, 2019

What’s New in Upstream Technologies

Recent upstream processing innovations include enhanced sensor technology, single-use bioreactors

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Articles BioPharma Downstream Upstream

February 28, 2019

Bispecific Antibody Purification: Insights and Case Studies

New modalities, like bispecific antibodies, present unique challenges compared to mAb production.

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Articles BioPharma Downstream Upstream

January 31, 2019

Modeling the Degradation of mAb Therapeutics

Ensuring the stability of biotherapeutic products, which has an impact on their safety and...

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Articles Upstream

January 17, 2019

Perfusion Culture Using TFF or ATF as Cell Retention Method

Perfusion processes have many advantages such as being favorable for product quality and...

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