Articles - Bioprocess Development Forum

Articles

February 24, 2022

Mechanistic vs Statistical Models

Mathematical models are recommended by the ICH Q8 guidelines on pharmaceutical development to...

Derek Author Smith

Articles BioPharma Downstream Upstream

January 13, 2022

Enhancing Resins Addresses Purification Concerns

There is ongoing enhancement of downstream chromatography resins as biomanufacturers...

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Articles Upstream

November 18, 2021

Scaling Up an E. coli Upstream Process for Plasmid DNA Production — from 2.5 to 160 L scale Fermenters

This article summarizes the results of Escherichia coli growth performance for plasmid...

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Articles Upstream

November 18, 2021

Maximum Output Starts with Optimized Upstream Processing

Significant growth in the development and manufacturing of biologics—from traditional recombinant...

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Articles BioPharma Downstream Upstream

November 4, 2021

Large-Scale Single-Use Bioreactors Prove Mettle Amid Growing Demand

The 2000-L-scale SUB has been the mainstay of large-scale SUBs since its introduction. Yasser...

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Articles Upstream

October 21, 2021

Cell Culture Media Selection Guide for Your Lab Wall

Doing cell culture and upstream process development on antibodies, vaccines, or viruses?

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Articles

October 21, 2021

Scalable AAV Production Process for Gene Therapy

Viral vectors are often used for gene transfer of specific tissue- or cell-type modifications.

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Articles

October 21, 2021

mRNA Vaccines: Current Trends and Perspectives

mRNA therapy is a rapidly growing field. The technology offers great benefit and potential for...

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Articles Downstream Upstream

September 9, 2021

Antibody Production Workflow

Antibody-based therapies have evolved beyond monoclonal antibodies (mAbs) to include bispecific...

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Articles BioPharma Downstream Regulatory Upstream

August 30, 2021

Cell-free Expression Systems Pose Cell Culture Alternative

Among the challenges in upstream bioprocessing is the cellular waste generated as a by-product...

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