Articles - Bioprocess Development Forum

Articles

September 27, 2018

How to Determine Dynamic Binding Capacity (DBC) of Chromatography Resins

In protein purification, dynamic binding capacity (DBC) of a chromatography column describes the...

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Articles Downstream

July 2, 2018

Developing an Efficient Adenovirus Downstream Purification Process

Adenovirus is one of the most frequently used viral vectors in the development of therapeutic...

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Articles BioPharma Downstream Upstream

July 2, 2018

Challenges in Cell Harvesting Prompt Enhancements

Cell harvesting is a crucial step that can have significant impact on product quality and…

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Articles BioPharma Downstream Regulatory

June 7, 2018

Putting Viral Clearance Capabilities to the Test

Drug products based on live cells have an inherent risk for viral contamination that could…

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Articles

May 24, 2018

Chromatography Scale-Up: Don’t Get Tied Down by Bed Height

When scaling, you can make better use of existing chromatography columns while avoiding overcapacity.

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Articles Multimedia

May 24, 2018

Cleaning Protein A Resins with 1 M NaOH

With increasing mAb titers, the impurity level of the cell culture feed increases. If not…

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Articles

May 9, 2018

Capacity and Performance of a Next Generation Protein A Chromatography Resin

MabSelect™ PrismA is a protein A resin of which both the ligand and the base…

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Articles BioPharma Regulatory

April 12, 2018

Understanding Validation and Technical Transfer, Part I

Many new biological entities use unique processing flows and steps that can require non-traditional...

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Articles Regulatory

March 13, 2018

Applying GMPs in Stages of Development

Regardless of the phase of development and the level of GMPs being applied, there should…

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Articles BioPharma Regulatory

March 1, 2018

Efficient Cleaning-In-Place Methods for Protein-Based Antibody Affinity Chromatography Resins

This whitepaper discusses cleaning of affinity resins for purifying monoclonal antibodies and Fab fragments…

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