Register to the webinar today
Trace metals in complex cell culture media (CCM) can have a significant impact on critical quality attributes of recombinant therapeutic proteins. Raw materials are perhaps the greatest sources of trace metals and are therefore the primary method manufacturers use to control trace metals in CCM.
Historically, ICP-MS has been favored for trace metal analysis due to its high sensitivity, detection, and quantification capabilities. However, it can be challenging to develop suitable methods for raw materials and complex products. USP<1023> has provided much needed guidance on this subject. Cytiva has developed in-house methods to test raw materials and complex CCM that meet and exceed requirements listed in USP<1023>. These test methods accurately and precisely detect metals in raw materials and complex CCM products and represent a cornerstone of the our raw material characterization program.
Here’s your opportunity to align your biomanufacturing processes with USP<1023> standards. Understanding how media composition impacts cell culture quality is essential for producing consistent, high-quality biotherapeutics. Join this webinar to explore the intricacies of United States Pharmacopeia chapter USP<1023> and gain valuable insights to improve your processes.
You will learn how to establish a comprehensive trace metal monitoring program that aligns with this guidance. And you will get practical tips for addressing challenges like matrix effects in inductively coupled plasma mass spectrometry (ICP-MS) and implementing risk scoring systems for raw materials.
Speaker:
- Nathan Israelsen, Senior Scientist, Cytiva
Dates:
- Option 1: Wed, Mar 12, 3:00 PM CET (Paris)
- Option 2: Wed, Mar 12, 2:00 PM EST (Boston)
- Option 3: Thu, Mar 13, 10:00 AM IST (Delhi)
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