Protein A - Bioprocess Development Forum

Articles Downstream

February 9, 2024

Get Started: Purification of mAb Variants – eLearning

The success of monoclonal antibodies (mAbs) as therapeutics and the multi-domain structure of...

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Articles

January 26, 2024

Chromatography innovations for the diversified antibody pipeline

Introducing MabSelect™ VH3 affinity resin for antibody variants. At Cytiva, we connect with...

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Articles Downstream

April 21, 2023

Optimization of a two-step purification method for bispecific antibodies

Bispecific antibodies (bsAbs) have gained increasing interest over recent years because they can...

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Articles Regulatory

May 20, 2021

Evaluation of Fibro PrismA for Scalable Single-Use mAb Purification

In clinical monoclonal antibody (mAb) manufacturing, capture on protein A chromatography resin gives...

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Articles BioPharma Downstream

January 17, 2019

A Look at the Affinity Chromatography Landscape

Affinity chromatography offers the high selectivity required for biopharmaceutical manufacturing and analysis. Specific binding...

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Articles

May 24, 2018

Chromatography Scale-Up: Don’t Get Tied Down by Bed Height

When scaling, you can make better use of existing chromatography columns while avoiding overcapacity.

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Articles Multimedia

May 24, 2018

Cleaning Protein A Resins with 1 M NaOH

With increasing mAb titers, the impurity level of the cell culture feed increases. If not…

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Articles

May 9, 2018

Capacity and Performance of a Next Generation Protein A Chromatography Resin

MabSelect™ PrismA is a protein A resin of which both the ligand and the base…

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Articles BioPharma Regulatory

March 1, 2018

Efficient Cleaning-In-Place Methods for Protein-Based Antibody Affinity Chromatography Resins

This whitepaper discusses cleaning of affinity resins for purifying monoclonal antibodies and Fab fragments…

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Articles BioPharma Downstream Upstream

August 11, 2017

Process Chromatography: Continuous Optimization

Cell-culture and fermentation are high-yielding processes that effectively produce...

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