upstream - Bioprocess Development Forum

Articles Upstream

January 12, 2023

rAAV Production Using HEK293 Cell Line and Transfection Medium

Improving the performance of a scalable AAV process in Xcellerex™ XDR-10 and XDR-200 bioreactor...

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Articles Upstream

October 21, 2021

Cell Culture Media Selection Guide for Your Lab Wall

Doing cell culture and upstream process development on antibodies, vaccines, or viruses?

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Articles Downstream Upstream

September 9, 2021

Antibody Production Workflow

Antibody-based therapies have evolved beyond monoclonal antibodies (mAbs) to include bispecific...

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Articles BioPharma Downstream Regulatory Upstream

August 30, 2021

Cell-free Expression Systems Pose Cell Culture Alternative

Among the challenges in upstream bioprocessing is the cellular waste generated as a by-product...

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Articles BioPharma Downstream Upstream

August 30, 2021

Single-Use Technologies Prove Effective for Viral Vector Process Development

Upstream viral-vector processes can have significant impacts on downstream purification requirements. The presence...

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Articles BioPharma Downstream Regulatory Upstream

January 14, 2021

Updating Viral Clearance for New Biologic Modalities

Viral clearance processes and guidance must evolve along with newer biotherapeutic modalities.

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Articles Downstream Upstream

July 30, 2020

Lentiviral Vector Upstream Process in Single-use Bioreactors

Lentiviruses exhibit many desirable properties as gene transfer vehicles, such as high transduction...

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Articles Downstream Upstream

March 12, 2020

Improving Upstream Predictability

In the earliest days of biotech, developers often struggled to sustain conditions that would...

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Articles BioPharma Downstream Upstream

February 27, 2020

Maximizing the Effectiveness of Upstream Bioprocessing Through the Combination of Lab Informatics and Instrumentation

The biopharmaceutical market continues to expand at a rapid pace and the demand for upstream...

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Articles Upstream

January 30, 2020

Fortem: One Film for Single-Use Bioprocessing

Single-use technology has been transforming the modern biomanufacturing workflow. Single-use...

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